M.Phil Pharmacology

INTRODUCTION TO PHARMACOLOGY AND ITS SCOPE:

PHARMACOKINETICS

Definition and clinical significance of pharmacokinetics, Physicochemical characteristics of
drugs, pharmacokinetic analysis, Zero-order and first-order Kinetics, One, two and multi
compartment models, Non compartmental kinetics, Kinetics of drug absorption, distribution
and elimination, half-life and volume of distribution in pharmacokinetics, Organ and whole
body clearance, Single dose, multiple dose and constant infusion kinetics, PK / PD
correlation, Non-linear Pharmacokinetics, Population pharmacokinetic Models and Bayesian
Forecasting applied to clinical pharmacokinetics

PHARMACODYNAMICS

Drug receptors and drug action, Specificity of drug action, Types of drug antagonism,
Potency and efficacy, Factors modifying the action & dosage of drugs, Drug dosing

PRINCIPLES OF DRUG DEVELOPMENT

History of drug discovery and development, modern techniques in drug screening, drug
development process, preclinical testing, clinical phases of drug development, regulatory
aspects of dd, Types of Drug applications, marketing and post marketing surveillance,
Generic drugs

1st Semester

2nd Semester

3rd and 4th Semesters